Saksham Kulkarni's big debut was as as a child actor in the character of Chiklu / Chikhlu in the movie Pak Pak Pakak. For this movie he also received the Best Male Actor award fora Marathi film at Asian Fest in Singapore. He also did a few movies later as a child actor. For his education, he has completed his Masters in Commerce. He later acted as an adult actor for the first time in the movie Kaksparsh. In 2012, he also debuted on TV with the comedy show Ambat God. Sanjay Mone, Vishaka Subedar, Suhas Paranjape and Vandana Gupte were his senior co-stars in this serial. Later, he also did a Hindi TV film along with Urmila Matondkar called Life Main Hungama Hai and performed in dance show Eka Peksha Ek Jodicha Mamla along with Gauri Vaidya. He also starred in a Hindi Movie Allah Ke Bande, along with Sharman Joshi.